Physical activity and brain oxygen: how does locomotion reshape hypoxic pockets?
Hypoxic pockets are brief, local drops in cortical oxygen that occur in the healthy brain and become less frequent when mice run. This project uses bioluminescence oxygen imaging in awake, head-fixed mice to ask how running, rest and transitions between them change the number, size and duration of hypoxic pockets.
What you will learn
In vivo widefield imaging in awake mice, behavioural tracking, time-series and image analysis in Python or MATLAB, and how to design and analyse a within-animal experiment.
Prerequisite: FELASA course, or willingness to complete it before the experimental phase.